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研究業績

査読有の欧文学術論文 (計97編, うち筆頭22編と責任6編，Impact Factor (IF); 2023年データ)

  1. Sato K, Hirayama Y, Mizutani A, Yao J, Higashino J, Kamitaka Y, Muranaka Y, Yamazaki K, Nishii R, Kobayashi M, Kawai K. Potential application of the myocardial scintigraphy agent [123I]BMIPP in colon cancer cell imaging. Int J Mol Sci. 2024;25(14):7747.doi: 10.3390/ijms25147747. IF=4.9
  2. Mizutani A, Kobayashi M, Nishi K, Fujita K, Takahashi K, Muranaka Y, Satou K, Kitamura M, Suzuki C, Nishii R, Shikano N, Magata Y, Ishida Y, Kunishima M, Fukuchi K, Kawai K. Development of radioiodine-labeled mequitazine for evaluation of hepatic CYP2D activity. Front. Pharmacol, 2024;15:1397288.doi: 10.3389/fphar.2024.1397288. eCollection 2024. IF=4.4
  3. Nishiyama Y, Mizutani A, Kobayashi M, Muranaka Y, Sato K, Maki H, Kawai K. SPECT imaging of P. aeruginosainfection in mice using 123I-BMIPP. Pharmaceutics. 2024;16:656.  https://doi.org/10.3390/pharmaceutics16050656. IF=4.9
  4. Muranaka Y, Matsue M, Mizutani A, Kobayashi M, Sato K, Kondo A, Nishiyama Y, Ohata S, Nishi K, Yamazaki K, Nishii R, Shikano N, Okamoto S, Kawai K. Evaluation of L-Alanine metabolism in bacteria for nuclear medicine imaging of bacterial infection. Int J Mol Sci. 2023;24(5):4775.IF=4.9
  5. Sato K, Mizutani A, Muranaka Y, Yao J, Kobayashi M, Yamazaki K, Nishii R, Nishi K, Nakanishi T, Tamai I, Kawai K. Biological distribution after oral administration of radioiodine-labeled acetaminophen to estimate gastrointestinal absorption function via OATPs, OATs and/or MRPs. Pharmaceutics. 2023;15(2):497. IF=4.9
  6. Sato K, Seki T, Mizutani A, Muranaka Y, Hirota S, Nishi K, Yamazaki K, Nishii K, Nakanishi T, Tamai I, Kawai K. Kobayashi M. A single high-dose irradiation changes accumulation of methotrexate and gene expression levels of SLC and ABC transporters in cancer cells. Front. Pharmacol. 2023;13:1069321. IF=4.4
  7. Yamazaki K, Nishii R, Mizutani Y, Makishima H, Kaneko T, Isobe Y, Terada T, Tamura K, Tani T, Kobayashi M, Wakamatsu M, Tsuji H, Higashi T. Estimation of post-therapeutic liver reserve capacity using 99mTc-GSA Scintigraphy prior to carbon-ion radiotherapy for liver tumors. Eur. J Nucl. Med. Mol. Imaging. 2023;50(2):581-592. 2022. doi: 10.1007/s00259-022-05985-5. IF=8.6
  8. Mizutani A, Kobayashi M, Aibe R, Muranaka Y, Nishi K, Kitamura M, Suzuki C, Nishii R, Shikano N, Magata Y, Ishida Y, Kunishima M, Kawai K. Measurement of hepatic CYP3A4 and 2D6 Activity using radioiodine-labeled O-Desmethylvenlafaxine. Int J Mol Sci. 2022;23(19):11458. IF=4.9
  9. Muranaka Y, Mizutani A, Kobayashi M, Nakamoto K, Matsue M, Takagi F, Okazaki K, Nishi K, Yamazaki K, Nishii R, Shikano N, Okamoto S, Maki H, Kawai K. 123I-BMIPP, a radiopharmaceutical for myocardial fatty acid metabolism scintigraphy, could be utilized in bacterial infection imaging. Pharmaceutics. 2022;14(5):1008. IF=4.9
  10. Mizutani A, Kobayashi M, Ohuchi M, Sasaki K, Muranaka Y, Torikai Y, Fukakusa S, Suzuki C, Nishii R, Haruta S, Magata Y, Kawai K. Indirect SPECT imaging evaluation for possible nose-to-brain drug delivery using a compound with poor blood-brain barrier permeability in mice. Pharmaceutics. 2022;14(5):1026. IF=4.9
  11. Muranaka Y, Mizutani A, Kobayashi M, Nakamoto K, Matsue M, Nishi K, Yamazaki K, Nishii R, Shikano N, Okamoto S, Kawai K. Comparison of L- and D-Amino acids for Bacterial Imaging at Lung Infection Mouse Model. Int J Mol Sci. 2022;23(5):2467. IF=4.9
  12. Kobayashi M, Mizutani A, Muranaka Y, Nishi K, Komori H, Nishii R, Shikano N, Nakanishi T, Tamai I, Kawai. K. Biological distribution of orally administrated [123I]MIBG for estimation of gastrointestinal tract absorption. Pharmaceutics. 2021;14(1):61. doi: 10.3390/pharmaceutics14010061. IF=4.9
  13. Nishi K, Kobayashi M, Kikuchi M, Mizutani A, Muranaka Y, Tamai I, Kawai K, Kudo T. Inhibition of the hepatic uptake of 99mTc-tetrofosmin using an organic cation transporter blocker. Pharmaceutics. 2021;13(7):1073. IF=4.9
  14. Rong-Hua T, Kobayashi M, Yang Y, Kleinerman E. Exercise inhibits Doxorubicin-induced damage to cardiac vessels and activation of Hippo/YAP-mediated apoptosis. Cancers(Basel). 2021;13(11):2740. IF=4.5
  15. Suga M, Nishii R, Miwa K, Kamitaka Y, Yamazaki K, Tamura K, Yamamoto N, Kohno R, Kobayashi M, Tanimoto K, Tsuji H, Higashi T. Differentiation between non-small cell lung cancer and radiation pneumonitis after carbon-ion radiotherapy by 18F-FDG PET/CT texture analysis. Sci Rep. 2021;11(1):11509. IF=3.8
  16. Kobayashi M, Mizutani A, Okamoto T, Muranaka Y, Nishi K, Nishii R, Shikano N, Nakanishi T, Tamai I, Kleinerman ES, Kawai K. Assessment of drug transporters involved in the urinary secretion of [99mTc]dimercaptosuccinic acid. Nucl Med Biol. 2021;94-95:92-7. IF=3.6
  17. Nishii R, Saga T, Sudo H, Togawa T, Kuyama J, Tani T, Maeda T, Kobayashi M, Iizasa T, Shingyoji M, Itami M, Kawamura K, Hashimoto H, Yamazaki K, Tamura K, Higashi T. Clinical Value of PET/CT with Carbon-11 4DST in the Evaluation of malignant and benign lung tumors. Ann Nucl Med. 2021;35(2):211-22. IF=2.5
  18. Kobayashi M, Mizutani A, Nishi K, Muranaka Y, Nishii R, Shikano N, Nakanishi T, Tamai I, Kleinerman ES, Kawai K. [131I]MIBG exports via MRP transporters and inhibition of the MRP transporters improves accumulation of [131I]MIBG in neuroblastoma. Nucl Med Biol. 2020;90-91:49-54. IF=3.6
  19. Kobayashi M, Nishi K, Mizutani A, Okudaira H, Nakanishi T, Shikano N, Nishii R, Tamai I, Kawai K. Transport mechanism and affinity of [99mTc]mercaptoacetyltriglycine ([99mTc]MAG3) on the apical membrane of renal proximal tubule cells. Nucl Med Biol. 2020;84-85:33-7. IF=3.6
  20. Kobayashi M, Nishi K, Mizutani A, Hokama T, Matsue M, Tsujikawa T, Nakanishi T, Nishii R, Tamai I, Kawai  K. Imaging of hepatic drug transporters with [131I]6-β-iodomethyl-19-norcholesterol. Sci Rep. 2019; 9(1):13413. IF=3.8
  21. Mukai K, Ogai K, Kobayashi M, Ueda T, Nakajima Y, Nakatani T. Longitudinal investigation of Propioni-bacterium acnes burden and skin physiological function during menstruation in healthy women. Structure and Function. 2019;18(1):20-30. IF=2.0
  22. Kobayashi M, Kato T, Washiyama K, Ihara M, Mizutani A, Nishi K, Flores LG 2nd, Nishii R, Kawai K. The pharmacological properties of 3-arm or 4-arm DOTA constructs for conjugation to a-melanocyte-stimulating hormone analogues for melanoma imaging. PLoS One. 2019;14(3):e0213397. IF=2.9
  23. Aoki M, Ogai K, Matsumoto M, Susa H, Yamada K, Yamatake T, Kobayashi M, Sugama J. Comparison of wiping methods for the removal of cleaning agent residue from hair follicles. Skin Res Technol. 2019;25(3):355-8. IF=2.0
  24. Aoki M, Ogai K, Kobayashi M, Minematsu T, Nakatani T, Okuwa M, Sanada H, Sugama J. Comparison of ceramide kinetics in the stratum corneum between dry skin and normal skin using animal models with fluorescent imaging method. Skin Res Technol. 2019;25(2):158-64. IF=2.0
  25. Shikano N, Yagi N, Nishii R, Ohe K, Nakajima S, Ogura M, Ikeda A, Kobayashi M, Yamaguchi N, Kawai K. Radioiodinated 6-iodo-D-meta-tyrosine: characterization of uptake in DLD-1 colon cancer cells and biodistribution in mice. ASVIP. 2019; 24:1-11. IF=0.0
  26. Shikano N, Yagi N, Nishii R, Nakajima S, Ogura M, Ikeda A, Kobayashi M, Yamaguchi N, Kawai K. Implications for the use of 6-radioiodinated L-meta-tyrosine as a tumor imaging agent: mouse biodistribution, renal autoradiography, and colon cancer DLD-1 cell studies. ASVIP. 2019;24:13-21. IF=0.0
  27. Kobayashi M, Tsujiuchi T, Mizutani A, Nishi K, Nakanishi T, Nishii R, Fukuchi K, Tamai I, Kawai K. Different efflux transporter affinity and metabolism of 99mTc-2-methoxyisobutylisonitrile and 99mTc-tetrofosmin for multidrug resistance monitoring in cancer. Pharm Res. 2018;36(1):18. IF=3.5
  28. Shrestha S, Singh P, Cortes-Salva MY, Jenko KJ, Ikawa M, Kim MJ, Kobayashi M, Morse CL, Zoghbi SS, Gladding RL, Fujita M, Innis RB, Pike VW. 1,2,4-Triazole-based Compounds as PET Radioligands for Imaging Brain COX-1 in Monkey. Part 2: Selection and Evaluation of [11C]PS13 for Quantitative Imaging. ACS Chem Neurosci. 2018;9(11):2620-7. IF=4.1
  29. Mizutani A, Kobayashi M, Fujita KI, Takahashi K, Hokama T, Takasu H, Nishi K, Nishii R, Shikano N, Fukuchi K, Kawai K. 123I-iomazenil whole-body imaging to detect hepatic carboxylesterase drug metabolizing enzyme activity. Nucl Med Commun.2018;39(9):825-33. IF=1.3
  30. Iuchi T, Tsuchiya S, Sato A, Dai M, Imran I, Kobayashi M, Sugama J. The changes of chronic leg oedema after recumbent position at night in chair-bound elderly Japanese individuals. Lymphoedema Research and Practice. 2018;6(1):1-9. IF=0.0
  31. Nishii R, Higashi T, Kagawa S, Arimoto M, Kishibe Y, Takahashi M, Yamada, Saiki M, Arakawa Y, Yamauchi H, Okuyama C, Hojo M, Munemitsu T, Sawada M, Kobayashi M, Kawai K, Nagamachi S, Hirai T, Miyamoto S. Diagnosis of brain tumors using system A amino acid transport PET imaging with C-11-MeAIB: A comparison study with C-11-methionine PET imaging. Contrast Media Mol Imaging. 2018;2018:1292746.. IF=3.2
  32. Tsujikawa T, Tsuyoshi H, Kanno M, Yamada S, Kobayashi M, Narita T, Kimura H, Fujieda S, Yoshida Y, Okazawa H. SelectedPET radiomic features remain the same. Oncotarget. 2018;9(29):20734-46. IF=0.0
  33. Matsumoto M, Ogai K, Aoki M, Urai T, Yokogawa M, Tawara M, Kobayashi M, Minematsu T, Sanada H, Sugama J. Changes in dermal structure and skin oxidative stress in overweight and obese Japanese males after weight loss: a longitudinal observation study. Skin Res Technolo. 2018;24(3):407-16. IF=2.0
  34. Zhu WJ, Kobayashi M, Yamada K, Mizutani A, Nishi K, Shikano N, Nishii R, Kunishima M, Kawai K. Development of radioiodine-labeled acetaminophen for specific, high-contrast imaging of malignant melanoma. Nucl Med Biol. 2018;59:16-21. IF=3.6
  35. Matsumoto M, Ogai K, Ohashi R, Tanaka K, Aoki M, Kobayashi M, Sugama J. Influences of different methods of cleaning agent removal on the effectiveness of skin dirt removal. The Society for Nursing Science and Engineering. 2018;5(1):22-30. IF=0.0
  36. Kobayashi M, Jiang T, Telu S, Zoghhi SS, Gunn R, Rabiner EA, Owen DR, Guo Q, Pike VW, Innis RB, Fujita M. 11C-DPA-713 has much greater specific binding to translocator protein 18 kDa (TSPO) in human brain than does 11C-(R)-PK11195. J Cereb Blood Flow Metab. 2018;38(3):393-403. IF=4.9
  37. Shikano N, Kusanagi K, Ogura M, Nakajima S, Serizawa Y, Hamai Y, Matsutani S, Kobayashi M, Kawai K.  Basic Study on Atherosclerosis Imaging: The Effect of Foam-cell Formation on S-[methyl-14C]-D/L-methionine Uptake by THP-1–derived Macrophages. ASVIP. 2018;23:1-8. IF=0.0
  38. Shikano N, Kusanagi K, Ogura M, Nakajima S, Serizawa Y, Hamai Y, Matsutani S, Kobayashi M, Kawai K, Shimokado K. Increased D-[S-methyl-14C]-methionine after co-loading of L-tyrosine ethyl ester in C6 glioma cells. ASVIP. 2018; 23: 9-16. IF=0.0
  39. Fujita M, Kobayashi M, Ikawa M, Gunn RN, RabinerEA, OwenDR, ZoghbiSS, HaskaliMB, TeluS, Pike VW, Innis RB. Comparison of four 11C-labeled PET ligands to quantify translocator protein 18 kDa (TSPO) in human brain: (R)-PK11195, PBR28, DPA-713, and ER176. EJNMMI Research. 2017;7:84. IF=3.1
  40. Iuchi T, Kobayashi M, Tsuchiya S, Ohno N, Dai M, Matsumoto M, Ogai K, Sato A, Sawazaki T, Miyati T, Tanaka S, Sugama J. Objective assessment of leg edema using ultrasonography with a gel pad. PLoS One. 2017;12:e0182042. IF=2.9
  41. Mukai K, Zhu WJ, Nakajima Y, Kobayashi M, Nakatani T. Non-invasive longitudinal monitoring of the angiogenesis in a murine excisional cutaneous wound healing model using a high-resolution three-dimensional ultrasound imaging. Skin Res Technolo. 2017;23:581-7. IF=2.0
  42. Ogai K, Matsumoto M, Aoki M, Ota R, Hashimoto K, Wada R, Kobayashi M, Sugama J. Wash or wipe? A comparative study of skin physiological changes between water washing and wiping after skin cleaning. Skin Res Technolo. 2017;23:519-24. IF=2.0
  43. Kagawa S, Nishii R, Higashi T, Yamaguchi H, Ogawa E, Okudaira H, Kobayashi M, Yoshimoto M, Shikano N, Kawai K. Relationship between [14C]MeAIB uptake and amino acid transporter family gene expression levels or proliferative activity in human carcinoma cells: comparison with [3H]Methionine uptake. Nucl Med Biol. 2017;49:8-15. IF=3.6
  44. Ono M, Barden A, Okudaira H, Kobayashi M, Kawai K, Oka S, Yoshimura H. Assessment of amino acid/drug transporters for renal transport of [18F]fluciclovine (anti-[18F]FACBC) in vitro. Int J Mol Sci. 2017;17(10): pii:E1730. IF=4.9
  45. Kobayashi M, Mizutani A, Nishi K, Nakajima S, Shikano N, Nishii R, Fukuchi K, Kawai K. Difference in accumulation and the transport mechanism of L- and D-methionine in high- and low-grade human glioma cells. Nucl Med Biol. 2017;44:78-82. IF=3.6
  46. Ogai K, Matsumoto M, Aoki M, Minematsu T, Kitamura K, Kobayashi M, Sanada H, Sugama J. Increased level of tumor necrosis factor-alpha (TNF-α) on the skin of Japanese obese males: measured by quantitative skin blotting. Int Journal Cosmet Sci. 2016;38(5):462-9. IF=2.7
  47. Kobayashi M, Matsunari I, Nishi K, Mizutani A, Miyazaki Y, Ogai K, Sugama J, Shiba K, Kawai K, Kinuya S. Stimultaneous acquisition of 99mTc and 123I-labeled radiotracers using a preclinical SPECT scanner with CZT detectors. Ann Nucl Med. 2016;30(4):263-71. IF=2.5
  48. Ono M, Oka S, Okudaira H, Nakanishi T, Mizokami A, Kobayashi M, Schuster DM, Goodman MM, Shirakami Y, Kawai K. [14C]Fluciclovine (alias anti-[14C]FACBC) uptake and ASCT2 expression in castration-resistant prostate cancer cells. Nucl Med Biol. 2015;42(11):887-92. IF=3.6
  49. Mizutani A, Matsunari I, Kobayashi M, Nishi K, Fujita W, Miyazaki Y, Nekolla SG, Kawai K. Impact of injection dose, post-reconstruction filtering, and collimator choice on image quality of myocardial perfusion SPECT using cadmium-zinc telluride detectors in the rat. EJNMMI Physics. 2015;2(1):7. IF=3.0
  50. Kobayashi M, Mori T, Tsujikawa T, Mizutani A, Ogai K, Sugama J, Kiyono Y, Kawai K, Okazawa H. Comparison of image quality with 62Cu and 64Cu-labeled radiotracers in Positron Emission Tomography whole-body phantom imaging. Hell J Nucl Med. 2015;18(2):103-7. IF=0.9
  51. Kobayashi M, Nishii R, Shikano N, Florens LG 2nd, Mizutani A, Ogai K, Sugama J, Nagamachi S, Kawai K. Development of radioiodine-labeled 4-hydroxyphenylcysteamine for specific diagnosis of malignant melanoma. Nucl Med Biol. 2015;42(6):536-40. IF=3.6
  52. Ogura M, Shikano N, Nakajima S, Sagara J, Yamaguchi N, Kusanagi K, Okui Y, Mizutani A, Kobayashi M, Kawai K. A strategy for improving FDG accumulation for early detection of metastasis for primary pancreatic cancer: stimulation of the Warburg effect in AsPC-1 cells. Nucl Med Biol. 2015;42(5):475-81. IF=3.6
  53. Ogai K, Matsumoto M, Minematsu T, Kitamura K, Kobayashi M, Sugama J, Sanada H. Development of an improved method for quantitative analysis of skin blotting: increasing reliability and applicability for skin assessment. Int J Cosmet Sci.2015;37(4):425-32. IF=2.7
  54. Nishi K, Mizutani A, Shikano N, Fujita K, Kobayashi M, Ono M, Nishii R, Sasaki Y, Kinuya S, Kawai K. In vivo radioactive metabolism analysis for individualized medicine: a basic study of a new method of CYP activity assay using 123I-IMP. Nucl Med Biol. 2014;42(2):171-6. IF=3.6
  55. Okudaira H, Oka S, Ono M, Nakanishi T, Shuster DM, Kobayashi M, Goodman MM, Tamai I, Kawai K, Shirakami Y. Accumulation of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in prostate cancer due to androgen-induced expression of amino-acid transporters. Mol Imaging Biol. 2014;16(6):756-64. IF=3.0
  56. Kobayashi M, Wakabayashi H, Kayano D, Konishi T, Kojima H, Okuda K, Yoneyama H, Tsushima H, Onoguchi M, Kawai K, Kinuya S. Application of a medium-energy collimator for I-131 imaging after ablation treatment of differentiated thyroid cancer. Ann Nucl Med. 2014;28(6):551-8. IF=2.5
  57. Miyazaki Y, Kobayashi M, Komatsu R, Hayashi A, Yonezawa S, Kawai K, Matsudaira M, Shiozaki J, Matsunari I. Effect of surrounding materials on iterative reconstruction based spatial resolution, and annihilations outside the source assessed by a small animal PET scanner. Ann Nucl Med. 2014;28(6):512-22. IF=2.5
  58. Matsunari I, Miyazaki Y, Kobayashi M, Nishi K, Mizutani A, Kawai K, Hayashi A, Komatsu R, Yonezawa R, Kinuya S. Performance evaluation of the eXplore speCZT preclinical imaging system. Ann Nucl Med. 2014;28(6):484-97. IF=2.5
  59. Kobayashi M, Nakanishi T, Nishi K, Higaki Y, Okudaira H, Ono M, Tsujiuchi T, Mizutani A, Nishii R, Tamai I, Arano Y, Kawai K. Transport mechanism of hepatic uptake and bile excretion in clinical hepatobiliary scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan. Nucl Med Biol. 2014;41(4):338-42. IF=3.6
  60. Yoneyama H, Tsushima H, Kobayashi M, Onoguchi M, Nakajima K, Kinuya S. Improved detection of sentinel lymph nodes in SPECT/CT images acquired using a low-medium-energy-general-purpose (LMEGP) collimator. Clin Nucl Med. 2014;39(1):e1-6. IF=9.6
  61. Kobayashi M, Wakabayashi H, Kojima H, Konishi T, Okuda K, Yoneyama H, Kayano D,　Tobisaka H, Tsushima H, Onoguchi M, Kawai K, Kinuya S. Prototype imaging protocols for monitoring the efficacy of iodine-131 ablation in differentiated thyroid cancer. Hell J Nucl Med. 2013;16(3):175-80. IF=0.9
  62. Nishii R, Higashi T, Kagawa S, Kishibe Y, Takahashi M, Yamauchi H, Motoyama H, Kawakami K, Nakaoku T, Nohara J, Okamura M, Watanabe T, Nakatani K, Nagamachi S, Tamura S, Kawai K, Kobayashi M. Clinical evaluation of an amino acid tracer, α-[N-methyl-11C]-methylaminoisobutyric acid ([11C]MeAIB), in the oncologic PET diagnosis of chest malignancies. Ann Nucl Med. 2013;27(9):808-21. IF=2.5
  63. Okudaira H, Nakanishi T, Oka S, Kobayashi M, Tamagami H, Schuster DM, Goodman MM, Shirakami Y, Tamai I, Kawai K. Kinetic analyses of trans-1-amino-3-18F- fluorocyclobutanecarboxylic acid transport in Xenopus laevis oocytes expressing human ASCT2 and SNAT2. Nucl Med Biol. 2013;40(5):670-5. IF=3.6
  64. Higaki Y, Kobayashi M, Uehara K, Hanaoka H, Arano Y, Kawai K. Appropriate collimators in a small animal SPECT scanner with CZT detector. Ann Nucl Med, 2013;27(3): 271-8. IF=2.5
  65. Nishi K, Kobayashi M, Nishii R, Shikano N, Takamura N, Kuga N, Yamasaki K, Nagamachi S, Tamura S, Otagiri M, Kawai K. Pharmacokinetic alteration of 99mTc-MAG3 using serum protein binding displacement method. Nucl Med Biol. 2013;40(3):366-70. IF=3.6
  66. Kobayashi M, Hashimoto F, Ohe K, Nadamura T, Nishi K, Shikano N, Nishii R, Higashi T, Okazawa H, Kawai K. Transport mechanism of 11C-labeled L- and D-methionine in human-derived tumor cells. Nucl Med Biol. 2012;39(8):1213-8. IF=3.6
  67. Fujita K, Sugiyama M, Akiyama Y, Hioki K, Kunishima M, Nishi K, Kobayashi M, Kawai K, Sasaki Y. N-Isopropyl-p-iodoamphetamine hydrochloride (IMP) is predominantly metabolized by CYP2C19. Drug Metab Dispos.2012;40(5):843-6.IF=4.4
  68. Kobayashi M, Mori T, Kiyono Y, Tsujikawa T, Maruyama R, Higaki Y, Shikano N, Nishii R, Kawai K, Kudo T, Okazawa H. Appropriate parameters of ordered-subset expectation maximization algorithm on measurement of myocardial blood flow and oxygen consumption with 11C-Acetate. Nucl Med Commun. 2012;33(2):130-8. IF=1.3
  69. Kobayashi M, Mori T, Kiyono Y, Tiwari VN, Maruyama R, Kawai K, Okazawa H. Cerebral oxygen metabolism of rats using injectable 15O-oxygen with a steady-state method. J Cereb Blood Flow Metab. 2012;32(1):33-40. IF=4.9
  70. Nakanishi T, Fukushi A, Sato M, Shirasaka Y, Ohe K, Kobayashi M, Kawai K, Tamai I. Functional characterization of apical transporters expressed in rat proximal tubular cells (PTCs) in primary culture. Mol Pharm. 2011;8(6):2142-50. IF=4.5
  71. Martinez ME, Kiyono Y, Noriki S, Inai K, Mandap KS, Kobayashi M, Mori T, Tokunaga Y, Tiwari VN, Okazawa H, Fujibayashi Y, Ido T. New Radiosynthesis of 2-deoxy-2-　[18F]fluoroacetamido-D-glucopyranose and its evaluation as a bacterial infections imaging agent. Nucl Med Biol. 2011;38(6):807-17. IF=3.6
  72. Tsujikawa T, Tsuchida T, Imamura Y, Kobayashi M, Asahi S, Shimizu K, Tsuji K, Okazawa H, Kimura H. Kikuchi-fujimoto disease PET/CT assessment of a rare cause of cervical lymphadenopathy. Clin Nucl Med. 2011;36(8):661-4. IF=9.6
  73. Okudaira H, Shikano N, Nishii R, Miyagi T, Yoshimoto M, Kobayashi M, Ohe K, Nakanishi T, Tamai I, Namiki M, Kawai K. Putative Transport Mechanism and Intracellular Fate of Anti-18F-FACBC (Trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid) in human Prostate Cancer. J Nucl Med. 2011;52(5):822-9. IF=9.3
  74. Kobayashi M, Kiyono Y, Maruyama R, Mori T, Kawai K, Okazawa H. Development of an H215O steady-state method combining a bolus and slow increasing injection with a multi-programming syringe pump. J Cereb Blood Flow Metab.2011;31(2):527-34. IF=4.9
  75. Oyama N, Hasegawa Y, Kiyono Y, Kobayashi M, Fujibayashi Y, Ponde DE, Dence C, Welch MJ, Yokoyama O. Early response assessment in prostate carcinoma by 18F-Fluorothymidine following anticancer therapy with docetaxel using preclinical tumour models. Eur J Nucl Med Mol Imaging. 2011;38(1):81-9. IF=8.6
  76. Shikano N, Kotani T, Nakajima S, Ogura M, Nakazawa S, Sagara J, Kobayashi M, Baba T, Yamaguchi N, Kubota N, Kawai K. Radioiodinated 4-iodo-L-meta-tyrosine, a system L selective artificial amino acid: molecular design and transport characterization in Chinese hamster ovary cells (CHO-K1 cells). Nucl Med Biol. 2010;37(8):903-10. IF=3.6
  77. Isozaki M, Arai Y, Kudo T, Kiyono Y, Kobayashi M, Kubota T, Kikuta K, Okazawa H. Clinical implication and prognosis of normal baseline cerebral blood flow with impaired vascular reserve in patients with major cerebral artery occlusive disease. Ann Nucl Med. 2010;24(5):371-7. IF=2.9
  78. Shikano N, Ogura M, Sagara J, Nakajima S, Kobayashi M, Baba T, Yamaguchi N, Iwamura Y, Kubota N, Kawai K. Uptake of 3-[125I]iodo-α-methyl-l-tyrosine into colon cancer DLD-1 cells: characterization and inhibitory effect of natural amino acids and amino acid-like drugs. Nucl Med Biol. 2010;37(2):197-204. IF=3.6
  79. Shikano N, Ogura M, Okudaira H, Nakajima S, Kotani T, Kobayashi M, Nakazawa S, Baba T, Yamaguchi N, Kubota N, Iwamura Y, Kubota N, Kawai K. Stimulation of 123I-3-iodo-α-methyl-L-tyrosine in chinese hamster ovary (CHO-K1) cells by tyrosine esters. Nucl Med Biol. 2010;37(2):189-96. IF=3.6
  80. Kobayashi M, Shikano N, Nishii R, Kiyono Y, Araki H, Nishi K, Oh M, Okudaira H, Ogura M, Yoshimoto M, Okazawa H, Fujibayashi Y, Kawai K. Comparison of the transcellular transport of FDG and D-Glucose by the kidney epithelial cell line LLC-PK1. Nucl Med Commun. 2010;31(2):141-6. IF=1.3
  81. Tiwari VN, Kiyono Y, Kobayashi M, Mori T, Kudo T, Okazawa H, Fujibayashi Y. Automatic labeling method for injectable 15O-oxygen using hemoglobin-containing liposome vesicles and its application for measurement of brain oxygen consumption by PET. Nucl Med Biol. 2010;37(1):77-83. IF=3.6
  82. Tsujikawa T, Yoshida Y, Kudo T, Kiyono Y, Kurokawa T, Kobayashi M, Tsuchida T, Fujibayashi Y, Kotsuji F, Okazawa H. Functional images reflect aggressiveness of endometrial carcinoma: estrogen receptor expression combined with FDG-PET. J Nucl Med.2009;50(10):1598-604. IF=9.3
  83. Hussain R, Tsuchida T, Kudo T, Kobayashi M, Tsujikawa T, Kiyono Y, Fujibayashi Y, Okazawa H. Vasodilatory effect of adenosine triphosphate does not change cerebral blood flow: a PET study with 15O-water. Ann Nucl Med. 2009;23(8):717-23.IF=2.9
  84. Hussain R, Kudo T, Tsujikawa T, Kobayashi M, Fujibayashi Y, Okazawa H. Validation of the calculation of the clearance rate constant (kmono) of [11C]acetate using parametric kmono image for myocardial oxidative metabolism. Nucl Med Biol. 2009;36(8):877-82. IF=3.6
  85. Kuga N, Shikano N, Takamura N, Nishii R, Yamasaki K, Kobayashi M, Nagamachi S, Tamura S, Kawai K. Competitive displacement of serum protein binding of radiopharmaceuticals with amino-acid infusion investigated with N-isopropyl-p-123I-iodoamphetamine. J Nucl Med. 2009;50(8):1378-83. IF=9.3
  86. Yoshii Y, Furukawa T, Yoshii H, Mori T, Kiyono Y, Waki A, Kobayashi M, Tsujikawa T, Kudo T, Okazawa H, Yonekura Y, Fujibayashi Y. Cytosolic acetyl-CoA synthetase affected tumor cell survival under hypoxia: the possible function in tumor acetyl-CoA/acetate metabolism. Cancer Sci. 2009;100(5):821-7. IF=4.5
  87. Oh M, Tanaka T, Kobayashi M, Furukawa T, Mori T, Fujieda S, Fujibayashi Y. Radio-cooper labeled Cu-ATSM: an indicator of quiescent but clonogenic tumor cells under mild hypoxia. Nucl Med Biol. 2009;36(4):419-26. IF=3.6
  88. Mandap KS, Ido T, Kiyono Y, Kobayashi M, Lohith TG, Mori T, Kasamatsu S, Kudo T, Okazawa H, Fujibayashi Y. Development of microwave-based automated nucleophilic [18F]fluorination system and its application for the production of [18F]flumazenil. Nucl Med Biol. 2009;36(4):403-9. IF=3.6
  89. Mori T, Sun LQ, Kobayashi M, Kiyono Y, Okazawa H, Furukawa T, Kawashima H, Welch MJ, Fujibayashi Y. Preparation and evaluation of ethyl [18F]fluoroacetate as a pro-radiotracer of [18F]fluoroacetate for the measurement of glial metabolism by PET. Nucl Med Biol. 2009;36(2):155-62. IF=3.6
  90. Lohith TG, Furukawa T, Mori T, Kobayashi M, Fujibayshi Y. Basic evaluation of FES-hERL PET tracer-reporter gene system for in vivo monitoring of adenoviral-mediated gene therapy. Mol Imaging Biol. 2008;10(5):245-52. IF=3.0
  91. Kobayashi M, Kudo T, Tsujikawa T, Isozaki M, Arai Y, Fujibayashi Y, Okazawa H. Shorter examination method for the diagnosis of misery perfusion using count-based OEF elevation in 15O-gas PET. J Nucl Med. 2008;49(2): 242-6. IF=9.3
  92. Tsujikawa T, Okazawa H, Yoshida Y, Mori T, Kobayashi M, Tsuchida T, Fujibayashi Y. Distinctive FDG and FES accumulation pattern of two tamoxifen treated patients with endometrial hyperplasia. Ann Nucl Med.2008;22(1):73-7. IF=2.5
  93. Tsujikawa T, Ohtsuka H, Morita N, Saegusa H, Kobayashi M, Okazawa H, Nishitani H. Does partial volume corrected maximum SUV based on count recovery coefficient in 3D-PET/CT correlate with clinical aggressiveness of non-Hodgkin lymphoma? Ann Nucl Med. 2008;22(1):23-30. IF=2.5
  94. Tsuchida T, Okazawa H, Mori T, Kobayashi M, Yoshida Y, Fujibayashi Y, Itoh H. In vivo imaging of estrogen receptor concentration in the endometrium and myometrium using FES PET-influence of menstrual cycle and endogenous estrogen level. Nucl Med Biol. 2007;34(2):205-10. IF=3.6
  95. Okazawa H, Tsuchida T, Kobayashi M, Arai Y, Pagani M, Isozaki M, Yonekura Y. Can reductions in baseline CBF and vasoreactivity detect misery perfusion in chronic cerebrovascular disease? Eur J Nucl Med Mol Imaging. 2007;34(1):121-9. IF=8.6
  96. Kobayashi M, Okazawa H, Tsuchida T, Kawai K, Fujibayashi Y, Yonekura Y. Diagnosis of misery perfusion using noninvasive O-15 gas PET. J Nucl Med. 2006;47(10):1581-6. IF=9.3
  97. Okazawa H, Tsuchida T, Pagani M, Mori T, Kobayashi M, Tanaka F, Yonekura Y. Effects of 5-HT1B/1D receptor agonist rizatriptan on cerebral blood flow and blood volume in normal circulation. J Cereb Blood Flow Metab. 2006;26(1):92-8. IF=4.9

2．査読有の和文学術論文 （計4編，うち筆頭2編）

  1. 浦井珠恵，松本勝，井内映美，小林正和，西村誠次，須釜淳子．エアマットレス使用時の枕のあて方が上肢・胸部の筋の硬さと自覚症状に及ぼす影響．Journal of Wellness and Health Care. 2018;41(2):151-8.
  2. 小林正和，田中利恵，松原孝祐，森岡茂晃，辻岡勝美，有村秀孝，上田克彦，小倉明夫，宮地利明．日本放射線技術学会の海外派遣事業における派遣者の動向及び業績の調査 日本放射線技術学会雑誌. 2017;73(10):1061-5.
  3. 小林正和, 杉本勝也, 丸山力哉, 工藤崇, 辻川哲也, 清野泰, 小野口昌久, 川井恵一, 藤林靖久, 岡沢秀彦. 18F-FDGを用いた脳PET検査の健常者データベースにおけるTransmission撮像および減弱補正法の影響. 日本放射線技術学会雑誌. 2010;66(1):42-8.
  4. 辻川哲也, 吉田好雄, 工藤崇, 清野泰, 黒川哲司, 小林正和, 土田龍郎, 藤林靖久, 岡沢秀彦. 子宮腫瘍性疾患におけるエストロゲン受容体とブドウ糖代謝の関連. 臨床放射線. 2008;53(10):1238-43.

3．査読無の学術論文 （計3編，うち筆頭1編）

  1. 小林正和．教育講座：放射線技術学を用いた先端生命科学研究－前臨床における腫瘍核医学イメージング－．放射線技術学会雑誌. 2018;74(12):1458-61．
  2. 岡沢秀彦，清野泰，Tiwari VN，森哲也，小林正和，藤林靖久．人工赤血球を用いた脳酸素代謝測定．人工血液.2010;18(3):97-101.
  3. 岡沢秀彦, 小林正和, 辻川哲也, 工藤崇, 清野泰, 藤林康久, Lohith TG, Tiwari VN．脳卒中治療に関連した分子プローブの開発と臨床応用の可能性．脳卒中. 2008;30(6):817-21.

4. 研究費

科学研究費

  1. 申請種目： 挑戦的研究(萌芽) (研究代表者)
    課題番号： 22K19504
    採択年度： 2022～2024年度
    研究課題：がん特異的グルタミノリシスを利用したミトコンドリア標的セラノスティクス薬剤の開発
  2. 申請種目： 基盤研究(B) (研究分担者)
    課題番号： 22H03016
    採択年度： 2022～2025年度
    研究課題： 細胞内レドックス制御を司るがん幹細胞治療の標的トランスポーター画像診断薬の開発
  3. 申請種目： 基盤研究(B) (研究分担者)
    課題番号： 22H03014
    採択年度： 2022～2025年度
    研究課題： 原発性アルドステロン症における新治療戦略ー安全かつ高奏功な根本治療の開発
  4. 申請種目： 基盤研究(B) (研究代表者)
    課題番号： 21H028655
    採択年度： 2021～2024年度
    研究課題： ナトリウム共役能動輸送型糖輸送体を標的としたセラノスティクス薬剤の開発
  5. 申請種目： 基盤研究(C) (研究代表者)
    課題番号： 18K07747
    採択年度： 2018～2020年度
    研究課題： 副作用が懸念される薬物の腎尿細管分泌機序の解明と新規腎機能核医学画像測定法の開発
  6. 申請種目： 国際共同研究加速基金(国際共同研究強化) (研究代表者)
    課題番号： 16KK0200
    採択年度： 2017～2020年度
    研究課題： 高精度多剤耐性予測法に基づく内用放射線治療の効果予測法とがん治療効果増強法の開発
  7. 申請種目： 基盤研究(C) (研究代表者)
    課題番号： 15K09949
    採択年度： 2015～2017年度
    研究課題： 抗がん剤の個別化治療を可能とするSPECTを利用した高精度多剤耐性予測法の確立
  8. 申請種目： 基盤研究(B) (研究分担者)
    課題番号： 25293260
    採択年度： 2013～2016年度
    研究課題： 精神神経疾患の個体差を克服する個別化薬物療法に有用な分子標的放射性診断薬の開発
  9. 申請種目： 挑戦的萌芽研究 (研究分担者)
    採択年度： 2015～2016年度
    課題番号： 15K15452
    研究課題： 癌関連トランスポーター発現解析に基づく機能性分子発現系による腫瘍診断薬の開発戦略
  10. 申請種目： 基盤研究(C) (研究代表者)
    採択年度： 2012～2014年度
    課題番号： 24601008
    研究課題： 半導体検出器を搭載した最新型小動物用SPECT/CT装置における定量測定法の確立
  11. 申請種目： 若手研究(B) (研究代表者)
    採択年度： 2010～2011年度
    課題番号： 22791180
    研究課題： 静注用15O標識薬剤による脳循環代謝測定の迅速化と薬物療法効果判定の有用性の検討
  12. 申請種目： 基盤研究(A) (研究分担者)
    採択年度： 2008～2011年度
    課題番号： 20249055
    研究課題： 脳内神経変性疾患に対する再生医療・遺伝子治療効果判定に有用な放射性診断薬の開発
  13. 申請種目： 若手研究(B) (研究代表者)
    採択年度： 2007～2009年度
    課題番号： 19790861
    研究課題： 急性期虚血性脳疾患におけるPET診断簡略化を目指した自動検出解析システムの開発

その他の外部資金

  • 20件

5. 特許18件 (筆頭8件)

  1. 小林正和, 川井恵一，水谷明日香，佐藤翔，平山佑香. 新規xCT機能活性測定剤、新規xCT機能活性の検査方法、新規がん放射性診断薬及び新規がんの検査方法. 特願2024-112072, 出願日2024.7.11
  2. 小林正和，川井恵一，水谷明日香, 松本拓也, 佐藤翔, 國嶋崇隆. がん関連アミノ酸輸送体ASCTの機能を測定するための検査薬. 特願2024-063732, 出願日2024.4.11
  3. 小林正和，川井恵一，絹谷清剛，玉井郁巳, 水谷明日香，佐藤翔，関達哉. SGLT機能画像診断薬. 特願2024-027025,出願日2024.2.27
  4. 川井恵一，小林正和, 水谷明日香，佐藤翔，平山佑香. xCT機能診断薬. 特願2023-028079, 出願日2023.2.27
  5. 小林正和，川井恵一，水谷明日香，村中由佳. 有機アニオントランスポーターの機能を測定するための検査薬. 特開2022-115260, 公開日2022.8.9
  6. 川井恵一，国嶋崇隆，小林正和，水谷明日香，北村正典，間賀田泰寛，鈴木千恵. 薬物代謝酵素活性を測定するための放射性フッ素標識画像診断薬. 特開2022-072154, 出願日2022.5.17
  7. 川井恵一，小林正和，水谷明日香，岡本成史，村中由佳. 細菌感染症の放射性診断薬．特許第7262747号，登録日2023.4.14
  8. 川井恵一，小林正和，水谷明日香，岡本成史，村中由佳. 細菌又は細胞の分類方法，アミノ酸の輸送特性の分類方法，菌感染の診断補助方法並びに癌の診断補助方法．特開2021-094023，公開日2021.6.24
  9. 川井恵一，小林正和，水谷明日香. 薬物代謝機能測定方法. 特許第7224629号, 公開日2020.8.31
  10. 小林正和，川井恵一，岡本成史，水谷明日香，松榮美希，森裕美子，湯淺善恵．細菌感染症の放射性診断薬．特許第7262747号，公開日2019.8.22
  11. 小林正和，川井恵一，加奈川優．心臓疾患診断剤，心臓疾患診断用組合せ医薬及び心臓疾患診断用キット．特開2017-128516，公開日2017.7.27
  12. 上田映美, 小林正和, 須釜淳子, 大貝和裕, 田中志信.　浮腫度の測定方法及びそれに用いる疑似組織体．特開2017-086454, 公開日2017.5.25
  13. 小林正和，川井恵一，玉井郁巳，中西猛夫，絹谷清剛，柴和弘．細胞増殖性疾患の治療用または診断用薬剤，特許第6474547号, 登録日2019.2.8
  14. 川井恵一，国嶋崇隆，北村正典，小林正和，水谷明日香．薬物代謝機能を測定するための検査薬，特許第6410351号, 登録日2018.10.5
  15. 川井恵一，玉井郁巳，國嶋崇隆，中西猛夫，小林正和．分子イメージングにより代謝機能を測定するための検査薬, 特許第6124273号, 登録日2017.4.14
  16. 小林正和，岡沢秀彦．PET薬剤送出装置およびその作動方法, 特許第5360466号, 登録日2013.9.13
  17. 吉井幸恵，藤林康久，清野泰，古川高子，森哲也，小林正和，吉井裕．がん幹細胞の検出剤並びにがん治療剤, 特許第5493911, 公開日2014.3.14
  18. 吉井幸恵，藤林康久，清野泰，古川高子，森哲也，小林正和，吉井裕．低酸素培養機器および無糖培地を用いたがん幹細胞濃縮法, 特許第521297号,　登録日2017.2.17

6. 受賞 13回

  1. 公益社団法人放射線技術学会中部支部 奨励賞(教育分野)
  2. 第5回看護理工学会学術集会・第11回看護実践学会学術集会・国際リンパ浮腫フレームワーク･ジャパン研究協議会第7回学術集会優秀ポスター賞
  3. 大阪ニュークリアサイエンス　ONSA奨励賞
  4. 金沢大学先端科学・イノベーション推進機構協力会第2回若手研究者奨励賞
  5. International Society for Biophysics and Imaging of the Skin (ISBS) World Congress2016 Best Poster Award
  6. 日本核医学会久田賞(Annals of Nuclear Medicine論文賞) 銅賞
  7. 第52回日本核医学学術総会　優秀ポスター賞　(技術部門第2位)
  8. 公益社団法人日本放射線技術学会 2012年度国外短期留学助成金
  9. 特定非営利活動法人日本核医学技術学会 2012年度国際交流研修派遣員(学術活動奨励部門)
  10. 財団法人山下太郎顕彰育英会　第22回山下太郎学術研究奨励賞
  11. 日本放射線技術学会　核医学分野　平成23年度技術奨励新人賞
  12. 第58回米国核医学会 年間優秀臨床論文賞
  13. 第58回米国核医学会 臨床腫瘍研究部門 最優秀ポスター賞


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